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目的:了解急性冠脉综合征(ACS)发作时热休克蛋白60(HSP60)及其抗体的血清浓度变化情况。方法:测定各类不稳定性心绞痛(UA,n=32)、S-T段抬高性心肌梗死(STEMI,n=16)和非ST段抬高性心肌梗死(NSTEMI,n=8)和健康对照(n=38)血清HSP60及其抗体的浓度并作统计学比较。结果:各型ACS患者血清HSP60和抗体水平均显著高于对照组(P<0.05),且STEMI患者血清HSP和抗体水平显著高于UA和NSTEMI患者(P<0.05)。结论:测定患者血清HSP60水平可以用于协助ACS诊断和疾病进程监测。
Objective: To investigate the change of serum concentration of heat shock protein 60 (HSP60) and its antibody in the onset of acute coronary syndrome (ACS). Methods: All types of unstable angina (UA, n = 32), ST-segment elevation myocardial infarction (STEMI, n = 16) and non-ST-segment elevation myocardial infarction (NSTEMI, n = 8) (n = 38) serum HSP60 and its antibody concentration and for statistical comparison. Results: The levels of serum HSP60 and antibody in all kinds of ACS patients were significantly higher than those in the control group (P <0.05). The levels of serum HSP and antibody in STEMI patients were significantly higher than those in UA and NSTEMI patients (P <0.05). Conclusion: The determination of serum HSP60 level in patients can be used to assist in the diagnosis of ACS and the monitoring of disease progression.