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目的:了解老年高血压病患者血清同型半胱氨酸(homocysteine,Hcy)高水平的老年高血压病患者尿微量白蛋白的变化。方法:对120例老年高血压病患者进行血清Hcy的测定及动态血压的测定,高Hcy组59例,正常Hcy组61例,比较两组尿微量白蛋白的水平。结果:高Hcy组患者尿微量白蛋白显著高于正常Hcy组[(22±4)μg/min vs.(15±4)μg/min,P<0.01]。结论:高Hcy组高血压病患者尿微量白蛋白升高,Hcy加重高血压病患者的肾损害。
Objective: To investigate the changes of urinary albumin in elderly hypertensive patients with high level of homocysteine (Hcy) in elderly patients with essential hypertension. Methods: Serum Hcy levels and ambulatory blood pressure were measured in 120 elderly hypertensive patients. The high Hcy group and the normal Hcy group were 59 and 61 respectively. The levels of urinary albumin in the two groups were compared. Results: Urine microalbumin in high Hcy group was significantly higher than that in normal Hcy group [(22 ± 4) μg / min vs. (15 ± 4) μg / min, P <0.01]. CONCLUSIONS: Urinary microalbuminuria is elevated in hypertensive patients with Hcy and Hcy is associated with renal impairment in hypertensive patients.