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目的观察干扰素联合病毒唑治疗慢性丙型肝炎的疗效。方法设干扰素和病毒唑联合治疗慢性丙型肝炎50例为治疗组,干扰素治疗慢性丙型肝炎46例为对照组。结果治疗组具有较高的ALT复常率(72.0%)和HCV-RNA阴转率(56.0%),随访半年后,治疗组ALT持续复常率(56.0%)及HCV-RNA持续阴转率(46.5)明显高于对照组,两组差异有显著性(P<0.01)。两药联用副反应无明显增加。结论干扰素和病毒唑联合治疗慢性丙型肝炎可提高疗效,值得推广。
Objective To observe the efficacy of interferon combined with ribavirin in the treatment of chronic hepatitis C Methods Interferon and ribavirin combined treatment of chronic hepatitis C 50 cases for the treatment group, interferon treatment of chronic hepatitis C 46 cases as control group. Results The treatment group had higher ALT normalization rate (72.0%) and HCV-RNA negative conversion rate (56.0%). After six months of follow-up, the sustained ALT rate (56.0% (46.5) was significantly higher than the control group, the difference between the two groups was significant (P <0.01). No significant increase in side effects of the two drugs combined. Conclusion Interferon and ribavirin combined treatment of chronic hepatitis C can improve the efficacy, it is worth promoting.