It is well known that lipid peroxide in low density lipoprotein (LDL) plays an important role in atherosclerosis and atherosclerotic diseases. We used oxidized LDL generated by incu-bating LDL from healthy persons with copper dichloride as a model to investigate the anti-lipid-peroxide property of Radix Salviae Miltiorrhizae Composita (RSMC) and ligustrazine. The changes in concentrations of lipid peroxide and lipids in LDL due to Cu++ were studied, and the effects of RSMC and ligustrazine on the changes were studied. The re-sults in our study indicate that RSMC has a potential role on and-lipid-peroxidation, but it was not found that ligustrazine has similar anti-peroxidation action. We are oxidized LDL generated by incu-bating LDL from healthy persons with copper dichloride as a model to investigate the anti-lipid- Peroxide properties of Radix Salviae Miltiorrhizae Composita (RSMC) and ligustrazine. The changes in concentrations of lipid peroxide and lipids in LDL due to Cu++ were studied, and the effects of RSMC and ligustrazine on the changes were studied. The re-sults in our study Indicates that RSMC has a potential role on and-lipid-peroxidation, but it was not found that ligustrazine has similar anti-peroxidation action.