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目的了解遗传与环境因素的交互作用对紧张反应易感性的影响。方法采用单纯病例研究设计,按照整群随机抽样方法抽取工作紧张测量量表(JSS)得分>90%正常参考值的323名汉族职员进行量表调查,采用Snapshot技术检测GCCR基因4个位点:Rs10482605、Rs41423247、Rs258747、Rs17209237,完成基因-环境交互作用的分析。结果 323名JSS得分较高的脑力作业者中,GCCR基因rs10482605突变型组工作紧张均分为(3.34±0.09)分,野生型组为(3.28±0.07)分,突变型组高于野生型组(P<0.05);GCCR基因rs17209237突变型组在生活事件总刺激项上均分为(49.41±15.60)分,高于野生型组均分(45.76±15.77)分(P<0.05);GCCR基因rs41423247突变型与主观支持有负相乘交互作用(P<0.05,OR=0.237)。结论 GCCR基因可能是紧张反应的遗传易感因素,且与环境因素(社会支持)存在交互作用。
Objectives To understand the effect of the interaction of genetic and environmental factors on the susceptibility to stress. Methods Using simple case study design, 323 Han staff members with JSS scores> 90% of normal reference value were enrolled in the questionnaire survey using cluster random sampling method. Four sites of GCCR gene were detected by Snapshot: Rs10482605, Rs41423247, Rs258747, Rs17209237 to complete the analysis of gene-environment interaction. Results Among 323 mental health workers with high JSS score, the work stress of GCCR gene rs10482605 mutation group was (3.34 ± 0.09) points and that of wild type group was (3.28 ± 0.07) points, and that of mutant group was higher than that of wild type group (P <0.05). GCCR gene rs17209237 mutant group was divided into (49.41 ± 15.60) points on the total stimulus of life events, which was significantly higher than that of the wild type group (45.76 ± 15.77) (P <0.05) The rs41423247 mutation had a negative multiplicative interaction with subjective support (P <0.05, OR = 0.237). Conclusion GCCR gene may be a genetic predisposition to stress response and interact with environmental factors (social support).