肠道病毒71型(Enterovirus71,EV71)是手足口病的主要病原体,是一种具有较强传染性和致病性的病毒,其流行范围波及全世界,近年来在亚太地区尤其是在中国的流行日趋频繁。目前EV71病原学、流行病学以及动物模型的研究均取得了一定进展,为疫苗的研发奠定了相应的基础,中国三家公司的EV71灭活疫苗现已率先获得临床批件,有望成为预防手足口病的有效手段。 Enterovirus 71 (EV71) is a major pathogen of hand, foot and mouth disease, is a highly contagious and pathogenic virus, its spread to the whole world, in recent years in the Asia Pacific region, especially in China Increasingly popular. At present, some progress has been made in the research on etiology, epidemiology and animal models of EV71, laying a solid foundation for the research and development of vaccines. The EV71 inactivated vaccine from three Chinese companies has taken the lead in obtaining clinical approval and is expected to become a preventive measure for hand, foot and mouth disease Effective means.