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目的探讨CA125在监测卵巢上皮性癌术后复发的界值。方法回顾性总结分析四川大学华西二院2005年1月至2009年12月收治的卵巢上皮性癌170例手术后患者,未复发组135例,复发组35例,以绝经后体格检查正常的105例妇女及除卵巢恶性肿瘤之外的65例术后无复发的妇科恶性肿瘤患者作为对照组。以CA125值为5kU/L、10kU/L、15kU/L、20kU/L、25kU/L、30kU/L、35kU/L分别作为界值,比较各界值对判断卵巢上皮性癌术后复发的敏感度、特异度。结果卵巢上皮性癌术后无复发患者、绝经后妇女及妇科恶性肿瘤术后患者CA125中位数值分别为7.5kU/L、8.4kU/L、6.9kU/L;均数±标准差分别为(8.3±3.6)kU/L、(9.1±4.2)kU/L、(7.3±2.6)kU/L。以15kU/L为界值判断复发,敏感度、特异度分别为74.3%、97.0%。结论以15kU/L为CA125界值配合影像学检查监测卵巢上皮性癌术后病情变化,敏感度提高,能够早期发现微小癌灶存在,早期治疗,延长患者生存期。
Objective To investigate the cutoff value of CA125 in monitoring postoperative recurrence of epithelial ovarian cancer. Methods Retrospectively analyzed and analyzed 170 cases of ovarian epithelial carcinoma patients who were treated in West China Hospital of Sichuan University from January 2005 to December 2009. There were 135 cases of non-recurrence group and 35 cases of recurrence group. The post-menopausal physical examination of normal 105 A total of 65 cases of gynecological malignancies without recurrence were included as control group, except for women and ovarian malignancies. The cutoff values of 5kU / L, 10kU / L, 15kU / L, 20kU / L, 25kU / L, 30kU / L and 35kU / L for the cutoff value of CA125 were compared to determine the sensitivity of postoperative recurrence of ovarian epithelial carcinoma Degree, specificity. Results The median of CA125 in postoperative patients with postoperative recurrence of ovarian epithelial cancer, postmenopausal women and patients with gynecologic malignancy was 7.5kU / L, 8.4kU / L and 6.9kU / L, respectively. The mean ± standard deviation was ( 8.3 ± 3.6) kU / L, (9.1 ± 4.2) kU / L, (7.3 ± 2.6) kU / L. With 15kU / L as the cutoff, the sensitivity and specificity were 74.3% and 97.0% respectively. Conclusions With 15kU / L as CA125 cutoff value, the change of postoperative condition of ovarian epithelial carcinoma is monitored and the sensitivity is improved. It can detect the presence of tiny cancers early and prolong the survival of patients.