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运用切断内侧副韧带及切除内侧半月板的方法，制作兔早期骨关节病动物模型，研究早期骨关节病的病理变化以及探讨早期骨关节病的发病机制。结果表明：术后５－１０天时，在扫描电镜显示关节软骨表面的胶原网架结构完整情况下，软骨细胞及基质中蛋白多糖已有明显变化。术后１５一３０天，扫描电镜显示软骨表面胶原网架结构裸露、断裂等改变；组织化学、组织学出现典型骨关节病变化。由此，本文提出一种骨关节病的发病机制，即在胶原网架结构完整的情况下，持续较小外力可先使胶原网架内的软骨细胞发生改变，然后造成胶原网架的破坏，再导致骨关节病的发生．
Using the method of cutting the medial collateral ligament and resecting the medial meniscus, an animal model of early osteoarthritis in rabbits was made to study the pathological changes of early osteoarthritis and to explore the pathogenesis of early osteoarthritis. The results showed that, after 5-10 days, the proteoglycan in chondrocytes and matrix had been changed obviously under the condition that the scanning electron microscope showed that the structure of collagen network on the surface of articular cartilage was intact. Fifteen to thirty days after operation, scanning electron microscopy showed that the structure of the collagen network on the cartilage surface was bare and broken. Histochemistry and histology showed typical changes of osteoarthrosis. Therefore, this paper presents a pathogenesis of osteoarthritis, that is, under the condition of complete collagen network structure, sustained small external force can make the chondrocytes in the collagen network frame change first, and then cause the destruction of the collagen network, And then lead to the occurrence of osteoarthritis.