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目的：志贺菌属的菌群分布因地区不同而存在差异。鉴于目前抗菌药物的滥用，菌群耐药性变化较大。本文分析１０６株志贺菌及药敏情况。方法：按常规法粪便培养，采用ＫＢ滤纸片法作药敏试验，并以标准菌株大肠埃希菌ＡＴＣＣ２５９２２质控。结果：福氏志贺菌９８株，宋内志贺菌７株；痢疾志贺菌１株，鲍氏菌未检出。１０６株志贺菌耐药率由低至高的排列顺序为：菌必治、卡那霉素、氟哌酸、丁胺卡那霉素、妥布霉素、庆大霉素、先锋Ⅴ、痢特灵、氯霉素、吡哌酸、复方新诺明、氨苄青霉素、苯唑青霉素、青霉素钠。结论：福氏志贺菌在急性菌痢患者中占绝对优势；建议临床医师选用抗菌药物应注意菌群耐药性的变化。
OBJECTIVE: The distribution of Shigella flora varies by region. In view of the current abuse of antimicrobial drugs, bacterial resistance changes. This article analyzes 106 strains of Shigella and susceptibility. Methods: According to the routine method of fecal culture, using KB filter paper method for susceptibility testing, and the standard strain of Escherichia coli ATCC25922 quality control. Results: 98 strains of Shigella flexneri, 7 strains of Shigella sonnei and 1 strain of Shigella dysenteriae were detected. The order of resistance of 106 strains of Shigella was from low to high: Bacillus subtilis, kanamycin, norfloxacin, amikacin, tobramycin, gentamicin, vanguard V, dysentery Trane, chloramphenicol, pipemidic acid, cotrimoxazole, ampicillin, oxacillin, penicillin sodium. Conclusion: Shigella flexneri is dominant in patients with acute bacillary dysentery. It is suggested that clinicians should pay attention to the change of antibiotic resistance in their use of antibiotics.