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本文对31名长期接铍者进行了以铍为抗原的白细胞移动抑制试验(LIT),研究该指标对慢性铍病的诊断价值。结果表明,机体接铍后白细胞移动功能受到抑制,对慢性铍病有较高的诊断特异性,其敏感性、准确性和诊断符合率均在80%以上。初步认为,LIT是一项铍过敏性免疫反应指标,并与肺部病变程度相平行,基本能反映出剂量-反应关系,是诊断慢性铍病较为理想的免疫诊断指标。
In this paper, 31 patients with long-term beryllium were beryllium anti-leukocyte migration inhibition test (LIT), the index of the diagnosis of chronic beryllium disease value. The results showed that leukocyte migration was inhibited after beryllium exposure and had high diagnostic specificity for chronic beryllium. The sensitivity, accuracy and diagnostic coincidence rate were above 80%. It is preliminarily believed that LIT is an indicator of beryllium allergic immune response and parallel to the degree of pulmonary lesion, which basically reflects the dose-response relationship and is an ideal immune diagnostic index for diagnosis of chronic beryllium disease.