论文部分内容阅读
目的：探索苯酐（ＰＡ）的慢性职业危害和对人体内微量元素的影响。方法：劳动卫生学调查和对８２名接触工人及对照组行医学检查。结果：长期接触较高浓度ＰＡ，鼻炎、皮炎发病率增高、哮喘加重，血清锌及特异性免疫球蛋白Ｇ水平增高；后者呈明显剂量－效应关系。结论：ＰＡ是一种致敏原，建议将特异性免疫球蛋白和血清锌作为ＰＡ慢性接触的一种生物监测指标。
Objective: To explore the chronic occupational hazards of phthalic anhydride (PA) and its effects on trace elements in human body. Methods: A survey of labor hygiene and medical examination of 82 exposed workers and control group. Results: Long-term exposure to higher concentrations of PA, rhinitis, dermatitis increased incidence of asthma increased serum zinc and specific immunoglobulin G levels increased; the latter showed a significant dose-effect relationship. CONCLUSIONS: PA is an allergen and suggests the use of specific immunoglobulins and serum zinc as a biomarker for chronic exposure to PA.