论文部分内容阅读
目的:探讨大鼠幼年期丰富环境经历对其成年后焦虑样行为和社会竞争行为的影响。方法:幼年期Wistar大鼠(生后21天)分为标准饲养组(对照组)和丰富环境刺激(EE)组。对照组为持续在标准实验室饲养条件下饲养;丰富环境组为生后21天至行为学检查时持续在丰富环境下饲养。在生后70天进行行为学检测:采用高架十字迷宫方法测试焦虑样行为;采用社会优势管道试验观察社会竞争性行为。结果:高架十字迷宫实验结果显示,与对照组相比,丰富环境组在开放臂的时间和次数显著增加;优势管道实验结果显示丰富环境刺激组大鼠的社会竞争力明显下降。结论:大鼠幼年期丰富环境刺激可改善大鼠的焦虑样情绪,但导致大鼠社会竞争力下降。
Objective: To investigate the effects of rich environmental experiences of juvenile rats on anxiety-like behaviors and social competitive behaviors in adulthood. Methods: The juvenile Wistar rats (21 days after birth) were divided into standard feeding group (control group) and rich environmental stimulation (EE) group. The control group was kept under standard laboratory feeding conditions. The rich environment group was kept in rich environment for 21 days after birth until behavioral examination. Behavioral tests were performed 70 days after birth: Anxiety-like behavior was measured using the elevated plus-maze method; social competitive behaviors were observed using socially superior pipeline tests. Results: The results of elevated plus maze experiment showed that the time and number of rich environment group in open arms increased significantly compared with control group. The results of superior pipeline experiment showed that the social competence of rats in enriched environment group decreased obviously. Conclusion: Enrichment of rats during the adulthood can improve the anxiety-like emotion in rats, but lead to the decline of social competitiveness in rats.