论文部分内容阅读
目的探讨依达拉奉对单肺通气老年患者肺功能的影响。方法择期拟行食管癌根治术患者40例,年龄60～75岁,体重指数(BMI)18～26 kg/m2,ASA分级Ⅰ或Ⅱ级,随机分为对照组(C组,n=20)和依达拉奉组(E组,n=20)。E组于入室后即刻,以60 mg/h速率静脉输注依达拉奉30 min,随后以7.5 mg/h的速率输注至术毕,C组采用同样方法静脉输注等容量生理盐水。分别于单肺通气前(T0)、单肺通气60 min(T1)、恢复双肺通气30 min(T2)记录CVP、HR、MAP和气道平均压(Pmean),同时采集桡动脉血样和颈内静脉血样进行血气分析,计算呼吸指数(RI)。结果两组T0时Pmean、PaO2和RI比较差异无统计学意义(P>0.05);与T0时比较,两组T1时和T2时Pmean和RI升高,PaO2降低(P<0.05);与C组比较,E组T1、T2时RI、Pmean降低和PaO2升高(P<0.05)。结论静脉输注依达拉奉可减轻单肺通气对老年患者肺功能的损害,具有肺保护作用。
Objective To investigate the effect of edaravone on pulmonary function in elderly patients with single lung ventilation. Methods Forty patients (aged 60-75 years, body mass index (BMI) 18-26 kg / m2, ASA grade Ⅰ or Ⅱ) were randomly divided into control group (n = 20), control group And edaravone group (group E, n = 20). In group E, edaravone was infused intravenously at a rate of 60 mg / h for 30 min immediately after infusion, and then infused at 7.5 mg / h. Group C received the same volume of normal saline intravenously. CVP, HR, MAP and mean airway pressure (Pmean) were recorded before single-lung ventilation (T0), single-lung ventilation for 60 min (T1) and double lung ventilation (T2) Venous blood samples were taken for blood gas analysis to calculate the respiratory index (RI). Results There was no significant difference in Pmean, PaO2 and RI between the two groups at T0 (P> 0.05). Compared with T0, Pmean and RI increased and PaO2 decreased at T1 and T2 (P <0.05) Group E, RI, Pmean decreased and PaO2 increased at T1 and T2 (P <0.05). Conclusion Intravenous edaravone can reduce lung function impairment of elderly patients by single lung ventilation and has lung protection.