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目的:观察替米沙坦治疗高血压病(EH)临床疗效及对心率变异性(heart rate variability,HRV)的影响。方法:对30例原发性高血压病人在替米沙坦治疗前后用动态心电图时域分析法对心率变异性各项指标进行了检测,并与对照进行比较。结果代表心率总变异程度的SDNN、SDANNI和SDNNI明显下降(P<0.01),代表迷走神经功能的指标YMSSD、PNN50也有所下降(P<0.05)。结论:替米沙坦不但能降低血压,改善症状,而且能提高心率变异性,改善预后。
Objective: To observe the clinical effect of telmisartan in the treatment of hypertension (EH) and its effect on heart rate variability (HRV). Methods: The indexes of heart rate variability (HRV) were measured in 30 patients with essential hypertension before and after treatment with telbivudine by dynamic electrocardiogram (ECG) time domain analysis and compared with the control. Results The SDNN, SDANNI and SDNNI, which represent the total variation of heart rate, were significantly decreased (P <0.01). The indexes YMSSD and PNN50, which represent vagal function, also decreased (P <0.05). Conclusion: Telmisartan can not only lower blood pressure, improve symptoms, but also improve heart rate variability and improve prognosis.