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目的:分析2009年6月～2011年12月广西先天性甲状腺功能减低症(CH)筛查情况及患病率,探讨不同地区CH的患病率及影响因素。方法:收集2009年6月～2011年12月广西筛查的427 402例新生儿,出生72 h后,采足跟末梢血制成干血滤纸片,用时间分辨荧光免疫法检测TSH浓度,并将初筛大于筛查切值者召回进行确诊检查。结果:2009年6月～2011年12月共筛查427 402例新生儿,初筛阳性可疑病例4 504例,确诊病例512例,CH患病率为1/835。山区、平原、沿海CH患病率不同,山区(1/772)高于平原(1/825)和沿海(1/1 142)地区(P<0.05)。3个地域均存在轻度碘缺乏,碘缺乏发生率分别为:山区6.9%,沿海6.7%,平原6.3%。结论:广西CH患病率居全国首位,不同地区CH患病率不同,地域环境因素对CH有一定影响。
Objective: To analyze the screening status and prevalence of congenital hypothyroidism (CH) in Guangxi from June 2009 to December 2011 and to explore the prevalence and influencing factors of CH in different areas. METHODS: A total of 427 402 newborns screened in Guangxi from June 2009 to December 2011 were collected. After 72 h of birth, dry blood filter paper was made from the heel and peripheral blood. The concentration of TSH was detected by time-resolved fluorescence immunoassay The screening is greater than the screening cut value of those who recall the diagnosis. Results: A total of 427 402 newborns were screened from June 2009 to December 2011. There were 4 504 positive screening cases, 512 confirmed cases and 1/835 CH. The prevalence of CH in mountainous, plain and coastal areas is different from that in the mountainous area (1/772) and plain (1/825) and coastal (1/1 142) areas (P <0.05). Three regions have mild iodine deficiency, iodine deficiency incidence rates were: 6.9% in mountainous area, 6.7% in coastal area and 6.3% in plain area. Conclusion: The prevalence of CH in Guangxi ranks the first in China, and the prevalence of CH in different areas is different. The regional environmental factors have some influence on CH.