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目的 研究丙型肝炎病毒 (HCV)基因型的流行病学特点。方法 采用INNO LIPA反向线形探针杂交法 ,对来自我国南方 (上海、武汉、徐州 )、北方 (北京、天津 )和东北 (大连、沈阳 ) 7市的10 7例慢性丙型肝炎患者进行了HCV基因型调查。结果 ①地域性 :HCV 1b是最主要的基因型 ,其检出率达 83 17% ,其中东北 2市 (72 2 2 % )低于北方 2市 (87 6 5 % ,P <0 0 1) ;2型的检出率较低 ,仅占6 86 % ;其余为 1b和 2型及 4h的混合型 ;②性别 :女性感染 1b的比例较高为 93 6 1% ,与男性 75 %比较 ,有极显著的统计意义 (P <0 0 1) ;③年龄 :1b检出率在 <30岁、30～ 49岁和 >5 0岁年龄组 ,分别为77 77%、83 92 %和 90 90 %。④感染时间 :1b的检出率在 >10年和 <10年感染期的病人中分别为10 0 %和 80 43% (P <0 0 1)。结论 丙型肝炎病毒基因型的分布和地域性、感染者的年龄、性别和感染时间有一定程度的关系。
Objective To study the epidemiological characteristics of hepatitis C virus (HCV) genotypes. Methods A total of 107 patients with chronic hepatitis C from 7 cities in South China (Shanghai, Wuhan, Xuzhou), North (Beijing, Tianjin) and Northeast (Dalian, Shenyang) were enrolled by INNO LIPA reverse linear probe hybridization HCV genotype survey. Results (1) Localization: HCV 1b was the most predominant genotype with a detection rate of 83.17%, of which, 2 cities in Northeast China (72.22%) were lower than 2 cities in northern China (87.65%, P <0.01) ; The detection rate of type 2 was lower, accounting for only 6 86%; the rest were mixed type 1 b, 2 and 4 h; ② gender: the higher proportion of women infected with 1b was 93 6 1%, compared with 75% (P <0.01); ③Age: The detection rate of 1b was 77 77%, 83 92% and 90 90 respectively in the groups of <30 years old, 30-49 years old and> 50 years old %. ④ Infection time: The detection rate of 1b was 10 0% and 80 43% (P 0 01) respectively in patients who were infected for> 10 years and <10 years. Conclusion The genotype distribution of hepatitis C virus has a certain degree of relationship with age, sex and infection time of infected persons.