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为研究Meynert基底核与纹状体边缘区以及脑内其他跟学习记忆有关的边缘系统结构间的关系，将海人藻酸注射于大鼠Meynert基底核后，观察c－fos原癌基因蛋白在脑内的表达。海人藻酸注射4h后，脑内只有少量c－fos阳性表达：海人藻酸注射8h后，脑内c－fos原癌基因蛋白表达增至最高峰。在海马、齿状回、中央杏仁核、纹状体、边缘区中有大量密集的c－foc阳性表达。在终纹床核、丘脑网状核、外侧隔核、丘脑下部视上核、室旁核、前下托及嗅内皮质等处可见较多c－foc阳性表达。在伏隔核、视前区、丘脑底核、黑质外侧部等部位可见少量c－fos阳性表达。海人藻酸注射Meynert基底核16h后，除海马、齿状回、中央杏仁核、纹状体及边缘区中有较多表达外，其余部位阳性标记基本消失。但脑腹侧的梨状前皮质、嗅结节、杏仁皮质核及前嗅核等部位出现大量的c－fos阳性表达。大脑皮质也可见较多c－fos阳性表达。海人藻酸注射48h后，脑内各部位的c－fos阳性反应均消失。本研究结果提示Meynert基底核和纹状体边缘区以及跟脑内其它与学习记忆有关的边缘系统结构间有密切的功能联系。
In order to study the relationship between the basal ganglia of Meynert and the marginal zone of the striatum and other limbic system structures associated with learning and memory in the brain, kainic acid was injected into the basal nucleus of Meynert in rats to observe the expression of c-fos proto-oncogene protein Brain expression. After exposure to alginic acid for 4h, there was only a small amount of c-fos expression in the brain: the expression of c-fos proto-oncogene increased to the highest level after 8h injection of kainic acid. In the hippocampus, dentate gyrus, central amygdala, striatum, marginal zone has a large number of intensive c-foc positive expression. C-foc positive expression was found in the nucleus of the dorsal horn, the thalamic reticular nucleus, the lateral septal nucleus, the supraoptic nucleus, the paraventricular nucleus, the anterior hypotaxis and the olfactory cortex. In the nucleus accumbens, the preoptic area, the subthalamic nucleus, the lateral substantia nigra and other parts of a small amount of c-fos positive expression. After injection of alginic acid for 16h, the positive marks disappeared in all the other parts except the hippocampus, dentate gyrus, central amygdala, striatum and marginal zone. However, a large amount of c-fos positive expression appeared in ventral preputial cortex, olfactory nodule, almond cortex nucleus and anterior olfactory tract nucleus. Cerebral cortex also showed more c-fos positive expression. After alginate injection for 48h, the c-fos positive reaction disappeared in all parts of the brain. The results of this study suggest that there is a close functional relationship between Meynert’s basal ganglia and striatum margins and other limbic system structures associated with learning and memory in the brain.