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在药物合成中,常用甲基或其它烃基保护酚羟基和羧基,使成酚醚和羧酸酯,反应完成后除去这些保护基时,因烷醚及酯的碳一氧键较稳定,往往要采用较激烈的条件。如脂肪醚用恒沸氢碘酸加热回流3～4小时后再加4倍量水,将反直中断裂的碘代烷蒸出,有机层用乙醚抽提、干燥,回收溶剂而得相应的醇。芳香—脂肪醚也可用氢碘酸去烃基,但芳核易发生碘代等副反应。48％的氢溴酸—冰醋酸(1:1)亦能用于碳原子较
In the synthesis of drugs, methyl or other hydrocarbyl commonly used to protect the phenolic hydroxyl and carboxyl, phenol and carboxylic acid ester into the ester, after the completion of the reaction to remove these protective groups, due to alkyl ether and ester carbon-oxygen bond more stable, often Use more intense conditions. Such as aliphatic ether with constant boiling hydrogen iodide heated to reflux for 3 to 4 hours plus 4 times the amount of water, the anti-straight broken alkyl iodide distilled off, the organic layer was extracted with ether, dried and the solvent was recovered to give the corresponding alcohol. Aromatic - aliphatic ether can also use hydroiodide to hydrocarbyl, but aromatic nuclei prone to iodine and other side reactions. 48% hydrobromic acid - glacial acetic acid (1: 1) can also be used for carbon atoms