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目的:探究干扰素联合LEEP(宫颈环形电切)术治疗宫颈上皮内瘤变临床的可行性。方法:选择2014年5月～2016年8月期间我院收诊的90例宫颈上皮内瘤变患者,依照随机数表法分为研究组(干扰素与LEEP联合治疗组)与对照组(单纯LEEP治疗组)各45例。对两组患者治疗后免疫功能与人乳头瘤病毒(HPV)连续感染状况进行对照分析。结果:经检测研究组患者治疗后免疫球蛋白IgG、IgA、IgM指标均显著大于对照组(P<0.05);观察组患者接受治疗后的HPV连续感染率明显低于对照组,差异有统计学意义(P<0.05)。结论:干扰素与LEEP联合方法用于治疗宫颈上皮内瘤变疾病,在强化患者免疫能力,以及降低HPV感染率方面发挥的作用是极为显著的,具有推广与应用价值。
Objective: To investigate the clinical feasibility of using interferon combined with LEEP (Cervical Circumction) in the treatment of cervical intraepithelial neoplasia. Methods: Ninety patients with cervical intraepithelial neoplasia who were treated in our hospital from May 2014 to August 2016 were randomly divided into study group (interferon and LEEP combined treatment group) and control group (simple LEEP treatment group) 45 cases each. After the treatment of two groups of patients with immune function and human papillomavirus (HPV) continuous infection status were analyzed. Results: After treatment, the immunoglobulin IgG, IgA and IgM indexes in the study group were significantly higher than those in the control group (P <0.05). The continuous infection rate of HPV in the observation group was significantly lower than that of the control group after treatment Significance (P <0.05). Conclusion: The combination of interferon and LEEP for the treatment of cervical intraepithelial neoplasia has an extremely significant role in enhancing the immune capacity of patients and reducing the HPV infection rate, and has the promotion and application value.