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用常规海马脑片实验方法，撤除人工脑脊液中的Mg2+，0.5h内CAl区出现自发性痫样放电，1h内趋于稳定，约1／3脑片波幅可稳定2h左右，但放电频率呈缓慢增加。无Mg2+灌流后1～3h间可以观察抗病药的作用。苯受英钠（PHT）100μmol/L，氯甲酸氮卓（CBZ）100μmol/L，安定（DZP）30μmol/L，苯巴比妥钠（PB）100μmol／L，而戊酸钠（VPA）10mmol/L见及乙琥胺（ESX）10mmol/L均可抑制波幅，量效关系明显。对频率和放电时程的抑制继发于波幅抑制，且缺乏量效关系。此模型可用来筛选广谱抗病药物，具有简便易行的优点，但不适合于长时间实验观察。
With conventional hippocampal slice method, the spontaneous epileptiform discharge occurred in CAl area within 0.5h after removal of Mg2 + in artificial cerebrospinal fluid, and stabilized within 1h. The amplitude of about 1/3 of the slices was stable for about 2h, but the discharge frequency was slow increase. No Mg2 perfusion after 1 ~ 3h can observe the role of anti-disease drugs. Benzene was treated with 100 μmol / L of PHT, 100 μmol / L of CBZ, 30 μmol / L of diazepam and 100 μmol / L of PB, and 10 mmol of VPA, / L see and Dosagel (ESX) 10mmol / L can inhibit the amplitude, the dose-effect relationship. Inhibition of the frequency and discharge duration is secondary to amplitude suppression and lacks the dose-effect relationship. This model can be used to screen broad spectrum disease-resistant drugs, with the advantages of simplicity, but not suitable for long-term experimental observations.