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目的：探讨转化生长因子β１ ，２（ｔｒａｎｓｆｏｒｍｉｎｇｇｒｏｗｔｈ ｆａｃｔｏｒβ１ ，２ ，ＴＧＦβ１ ，２） 及其ＩＩ 受体（ＴＧＦβＴｙｐｅ ⅡＲｅｃｅｐｔｏｒ ，ＴＧＦβＲ Ⅱ） 在胶质瘤表达与其恶性度关系和发生发展关系。方法： 用ＬＳＡＢ 免疫组化法检测星形细胞瘤４１例，其中Ｉ～ＩＩ级１６ 例，ＩＩＩ～ＩＶ 级２５ 例和正常对照１１ 例的ＴＧＦβ１ ，２ 及其ＲＩＩ 表达。结果：半定量示ＴＧＦβ１ ，２ 在正常脑组织、ＩＩＩ 级和ＩＩＩＩＶ 级胶质瘤三者的表达呈现从弱到强的正相关关系，有显著差别（ Ｐ＜ ０－０５） ；ＴＧＦβＲＩＩ在三者表达呈现从强到弱的负相关关系，有显著差别（ Ｐ＜ ０－０１） 。结论： 胶质瘤ＴＧＦβ１ ，２ 从弱到强表达和ＴＧＦβＲＩＩ从强到弱表达，提示其恶性不断升高；ＴＧＦβＲＩＩ 表达不断减弱，促进胶质瘤发生和发展。
Objective: To investigate the relationship between the expression of transforming growth factor β1 ,2 ,TGFβ1 ,2 and TGF β Type II Receptor , TGF βR II in glioma and its malignancy and its occurrence Develop relationships. Methods: Forty-one cases of astrocytomas were detected by LSAB immunohistochemistry. The expression of TGF-β1, 2 and RII in 16 cases of grade I-II, 25 cases of grade III-IV, and 11 cases of normal controls. Results: The expression of TGFβ1 ,2 in normal brain tissue, grade III and grade IIIIV gliomas showed a positive correlation from weak to strong in semi-quantitative analysis (P<0-05). TGF-βRII showed a negative correlation from strong to weak in the three expressions, with significant differences (P<0-01). Conclusion: The expression of TGF-β1,2 from weak to strong expression of gliomas and the expression of TGFβRII from strong to weak suggest that the malignancy is increasing. The expression of TGFβRII is constantly weakened, which promotes the occurrence and development of glioma.