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目的:观察中西医结合治疗难治性肾病综合征的疗效。方法:40名难治性肾病综合征患者,随机分为治疗组及对照组,均给予激素及免疫抑制剂(环磷酰胺),治疗组在此基础上予以中药(基础药物为黄芪、丹参、当归、茯苓、白术、泽泻、红花、桃仁、川芎、山楂)辨证论治;疗程结束后观察疗效及生化指标。结果:所有患者均完成研究,对照组有效率80%,治疗组有效率95%。两组疗效比较差异有统计学意义(P<0.05)。两组24小时尿蛋白定量及血浆白蛋白、肾功能比较,差异有统计学意义(P<0.05)。所有患者在治疗期间均无严重不良反应发生。结论:中西医结合治疗难治性肾病综合征优于单纯西医治疗。
Objective: To observe the curative effect of integrated traditional Chinese and western medicine on refractory nephrotic syndrome. Methods: Forty patients with refractory nephrotic syndrome were randomly divided into treatment group and control group. Hormone and immunosuppressive agents (cyclophosphamide) were given. The treatment group was given traditional Chinese medicine (astragalus root, salvia miltiorrhiza, Angelica, Poria, Atractylodes, Alisma, safflower, peach kernel, Chuanxiong, hawthorn) syndrome differentiation treatment; after the end of treatment efficacy and biochemical indicators. Results: All patients completed the study, the control group was 80% efficient, the treatment group 95%. The difference between the two groups was statistically significant (P <0.05). The two groups of 24-hour urine protein and serum albumin, renal function, the difference was statistically significant (P <0.05). All patients during treatment did not occur serious adverse reactions. Conclusion: Integrative treatment of refractory nephrotic syndrome is better than Western medicine alone.