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目的:观察他汀类与钙拮抗剂药物对颈动脉内膜-中膜厚度的影响。方法:40例高脂血症患者进行超声测定颈动脉内膜-中膜厚度(IMT),分为增厚组(治疗组)与正常组(对照组)各20例。对照组给予辛伐他汀片20mg、1次/d口服,治疗组在此基础上加服尼莫地平20mg、3次/d口服,随访12个月。结果:联合治疗组颈动脉内膜-中膜厚度及部分生化指标等有所下降(P<0.01,P<0.05)。结论:应用辛伐他汀与尼莫地平治疗IMT可抑制病变部位血管内膜增生,具有一定抗动脉硬化作用。
Objective: To observe the effects of statins and calcium antagonists on intima-media thickness of carotid artery. Methods: Forty patients with hyperlipidemia underwent carotid intima - media thickness (IMT) measurement, divided into thickening group (treatment group) and normal group (control group), 20 cases each. Control group was given simvastatin tablets 20mg, 1 times / d orally, on the basis of the treatment group plus nimodipine 20mg, 3 times / d orally, followed up for 12 months. Results: The intima - media thickness and some biochemical indexes of carotid arteries decreased in combination therapy group (P <0.01, P <0.05). Conclusion: The application of simvastatin and nimodipine in the treatment of IMT can inhibit the intimal hyperplasia of the lesion, and has a certain anti-atherogenic effect.