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采用前瞻性、双盲随机方法自孕28w起给具有妊高征高危因素的孕妇连续服用1.5g/d钙元素直至分娩。结果显示:服钙组、安慰剂组及正常孕妇对照组妊高征发生率分别为9.52%(6/63)、23.33%(14/60)及12.50%(8/64),服钙组和安慰剂组发生率差异显著。服钙组在妊娠病理、分娩期并发症、分娩方式及新生儿有关情况方面与安慰剂组、正常孕妇对照组比较没有显著差异。提示:孕28w后每日补1.5g钙元素可以降低妊高征高危人群的妊高征发生率;且并不增加围产期结局的危险性,对母儿均安全。故对有妊高征高危因素的孕妇补钙或改变膳食结构,多吃富含钙质的食物对预防妊高征具有实用价值。
A prospective, double-blind, randomized trial of pregnant women with risk factors for pregnancy-induced hypertension took 1.5 g / day of calcium supplementation until delivery from 28 weeks after birth. The results showed that the incidence of PIH was 9.52% (6/63), 23.33% (14/60) and 12.50% (8/64) in the calcium control group, the placebo group and the normal pregnant women control group respectively ), The difference between the calcium group and the placebo group was significant. Calcium group in pregnancy pathology, complications during childbirth, mode of delivery and neonatal situation with the placebo group, normal pregnant women control group no significant difference. Tip: pregnant 28w after daily supplement of 1.5g of calcium can reduce the risk of pregnancy-induced hypertension high risk of pregnancy-induced hypertension rate; and does not increase the risk of perinatal outcomes, both mother and child are safe. Therefore, pregnant women with PIH risk factors of calcium or change the diet, eat more foods rich in calcium to prevent pregnancy-induced hypertension syndrome has practical value.