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目的:探讨康复新液对口腔溃疡患者EGF、EGFR影响及疗效机制。方法:选取我院收治的口腔溃疡患者300例,根据治疗方法的不同,分为两组,每组各150例。试验组150例,予康复新液10 m L口含5 min后咽下,日3次,7 d为1个疗程,治疗1个疗程;对照组150例,予碘甘油涂布,日3次,7 d为1个疗程,治疗1个疗程。治疗后,观察并比较两组患者的溃疡持续时间、疼痛指数,EGF、EGFR情况,以及临床疗效。结果:与对照组相比较,试验组的溃疡持续时间、疼痛指数明显降低(P<0.05),EGF、EGFR情况改善(P<0.05),临床疗效显著提高(P<0.05),CRP水平降低(P<0.05)。结论:康复新液治疗口腔溃疡能够缩短溃疡持续时间,降低疼痛指数,改善EGF、EGFR,临床效果显著,值得临床推广使用。
Objective: To investigate the effect of Kangfuxin solution on EGF and EGFR in oral ulcer patients and its therapeutic mechanism. Methods: 300 cases of oral ulcer admitted to our hospital were selected and divided into two groups (150 cases in each group) according to the different treatment methods. 150 cases in the experimental group were treated with Kangfuxinxin 10 m L mouth for 5 minutes and then swallowed for 3 times daily for 7 days for 1 course of treatment. The control group of 150 cases were given iodine glycerol 3 times daily , 7 d for a course of treatment, treatment of a course of treatment. After treatment, the duration of ulcer, pain index, EGF, EGFR status and clinical efficacy were observed and compared between the two groups. Results: Compared with the control group, the duration of ulcer and the pain index in the experimental group were significantly decreased (P <0.05), the EGF and EGFR levels were improved (P <0.05), the clinical efficacy was significantly increased (P <0.05) P <0.05). Conclusion: The treatment of oral ulcer with Kangfuxinye can shorten the duration of ulcer, reduce the pain index and improve the EGF and EGFR. The clinical effect is worthy of clinical promotion.