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目的 系统评价基于Spearman相关系数的脑电双频指数(bispectral index,BIS)与Richmond镇静躁动评分(Richmond agitation sedation scale,RASS)和镇静-躁动评分(sedation-agitation scale,SAS)的相关性.方法 计算机检索PubMed、EMbase、Web of Science、The Cochrane Library (2016年7期)、CNKI、VIP、WanFangData和CBM数据库,检索时限均为从建库至2016年7月,查找关于BIS与RASS和(或)SAS评价ICU机械通气早期患者镇静深度的研究.由两位评价者独立筛选文献、提取资料、评价纳入研究的偏倚风险后,采用Comprehensive Meta Analysis 3.0软件进行Meta分析.结果 共纳入12个研究,包括397例患者.Meta分析结果显示:BIS与RASS和SAS的相关系数分别为[0.742,95％ CI (0.678,0.795)]和[0.605,95％ CI (0.517,0.681)].结论 BIS与RASS和SAS具有良好的相关性,可能为评价ICU机械通气早期患者镇静深度的提供更多选择.“,”Objective To assess the correlation between bispectral index (BIS) and richmond agitation sedation scale (RASS) and sedation-agitation scale (SAS) through the spearman correlation coefficient by systematic review.Methods Databases including PubMed,EMbase,Web of Science,The Cochrane Library (Issue 7,2016),CNKI,VIP,WanFang Data and CBM were searched from inception to July 2016 to collect literature on the correlation between BIS and RASS and SAS.The studies were screened according to the inclusion and exclusion criteria.After extracting data and assessing the quality of the included studies,meta-analysis was conducted using Comprehensive Meta Analysis 3.0 software.Results A total of 12 studies involving 397 patients were included.BIS was positively correlated with RASS score and SAS,and the summary correlation coefficient was 0.742 with 95％ CI 0.678 to 0.795 and 0.605 with 95％ CI 0.517 to 0.681,respectively.Conclusion BIS has a good correlation with RASS and SAS,which will provide more options for assessing sedation of patients with mechanical ventilation in ICU.