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目的探讨检测糖链抗原19-9(CA19-9)、癌胚抗原(CEA)及腺苷脱氢酶(ADA)对鉴别胸腔积液性质的临床价值。方法分别对40例恶性及良性胸腔积液患者中CA19-9、CEA、ADA含量水平检测,计算两组中三个指标的表达情况、单独及联合检测阳性率,以及对恶性胸腔积液的敏感性、特异性及诊断符合率。结果两组间三个指标含量差异均具有统计学意义(P<0.05);联合检测可以提高检测阳性率及诊断符合率,其中以CEA+ADA最好,其敏感性、特异性及诊断符合率分别为97.5%、87.5%、92.5%。结论 CA19-9、CEA在恶性胸腔积液中含量增高,ADA含量降低;CEA与ADA联合检测有助于提高恶性胸腔积液的检测价值。
Objective To investigate the clinical value of detecting carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA) and adenosine dehydrogenase (ADA) in differentiating pleural effusion. Methods The levels of CA19-9, CEA and ADA in 40 patients with malignant and benign pleural effusions were measured. The expression of three indicators in both groups were calculated. The positive rate of single and combined detection and the sensitivity to malignant pleural effusion Sex, specificity and diagnostic coincidence rate. Results The differences of the three indexes between the two groups were statistically significant (P <0.05). The combined detection could improve the detection positive rate and the diagnostic coincidence rate. The best CEA + ADA, the sensitivity, specificity and diagnostic coincidence rate Respectively 97.5%, 87.5%, 92.5%. Conclusions The levels of CA19-9 and CEA in malignant pleural effusion are higher and the content of ADA is lower. Combined detection of CEA and ADA is helpful to improve the detection value of malignant pleural effusion.