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目的:探讨中青年患者(年龄≤55岁)冠状动脉粥样硬化程度与生活应激事件评分的相关性。方法:对疑诊冠心病的164例中青年患者以标准Judkins法行冠状动脉造影术,计算机定量分析系统(QCA)分析冠状动脉狭窄程度并计算其冠状动脉病变积分(CAS),根据CAS分为3组:轻度狭窄组(n=74),中度狭窄组(n=60),重度狭窄组(n=30)。采用生活事件心理应激评定量表(LCU)对每位患者生活事件心理应激加以评分。结果:3组患者的LCU分别为:3.8±3.4,8.9±3.7和12.7±2.4,差异有统计学意义(P<0.05),LCU随着CAS的增加而升高,两者呈正相关(r=0.41,P<0.05),LCU>300是冠脉粥样硬化的一个独立预测指标(OR=9.05,P=0.001)。结论:生活应激是中青年冠脉粥样硬化的一个独立危险因素。
Objective: To investigate the correlation between the degree of coronary atherosclerosis and the score of life stress in middle-aged and young patients (age≤55 years). Methods: A total of 164 middle-aged and young patients with suspected coronary artery disease underwent coronary angiography by the standard method of Judkins, and the degree of coronary artery stenosis was calculated by computerized quantitative analysis system (QCA). The coronary artery disease score (CAS) Group 3: mild stenosis group (n = 74), moderate stenosis group (n = 60), severe stenosis group (n = 30). The psychological stress of life events in each patient was scored by using Life Events Psychological Stress Rating Scale (LCU). Results: The LCU of three groups were 3.8 ± 3.4, 8.9 ± 3.7 and 12.7 ± 2.4, respectively (P <0.05). The LCU increased with the increase of CAS, and there was a positive correlation between them (r = 0.41, P <0.05). LCU> 300 was an independent predictor of coronary atherosclerosis (OR = 9.05, P = 0.001). Conclusion: Life stress is an independent risk factor for coronary artery atherosclerosis in young people.