本文旨在复习B细胞慢性淋巴细胞白血病(慢淋)的临床和生物学的重要进展并提出今后的研究趋向。临床和实验室发现慢淋获早期确诊的病例已从1980～1985年间的29%上升到1985～1990年间的39%。诊断慢淋的最低条件应包括外周血成熟淋巴细胞持续增多(>10×10~9/L),骨髓象中淋巴细胞比例至少占30%。若淋巴细胞数在5～10×10~9/L时,应说明其持 This article aims to review the clinical and biological advances in B-cell chronic lymphocytic leukemia and to propose future research trends. Clinical and laboratory findings indicate that early diagnosis of chronic lean cases has risen from 29% between 1980 and 1985 to 39% between 1985 and 1990. The minimum condition for diagnosis of chronic lymphocytic leukemia should include the continuous increase of peripheral blood mature lymphocytes (> 10 × 10 ~ 9 / L) and the proportion of lymphocytes in bone marrow at least 30%. If the number of lymphocytes in the 5 ~ 10 × 10 ~ 9 / L, it should be said that the holding