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药物的药效取决于药物的化学结构,也受到剂型和给药途径的影响。药物的作用是多方面的,有副作用,也有或高或低的毒性。为了使一种药物能充分发挥作用,克服其生物学和药学方面的缺点,可以采用制备前体药物的方法,即对其化学结构进行化学修饰,改变其理化性质,从而改善其吸收、分布和排泄,以克服其缺点,有利于药效的充分发挥。药物制成前体药物后,对药物作用的改善已有不少综述,本文按药物结构讨论
The potency of the drug depends on the chemical structure of the drug and also on the dosage form and route of administration. Drugs are multifaceted, have side effects, and have high or low toxicity. In order for a drug to work adequately and to overcome its biological and pharmaceutical shortcomings, methods of making prodrugs, that is, chemically modifying its chemical structure, changing its physico-chemical properties, thereby improving its absorption, distribution and Excretion to overcome its shortcomings is conducive to the full effect of the drug. Drugs made of prodrugs, the improvement of the role of drugs have been a lot of reviews, this article according to the drug structure