幽门螺杆菌(Hp)已经被认为是各种胃肠疾患如胃炎、消化性溃疡的病原因子,然而大多数感染者是无症状的,近来的研究甚至显示Hp在机体抵抗其他胃肠病原菌中发挥重要作用。本研究显示Hp具有自身耐受的抗菌活性,并且发现该抗菌活性是由核糖体蛋白L1(RpL1)具有的杀菌肽样(cecropin-like)N端肽所决定的。 Helicobacter pylori (Hp) has been considered as the causative agent of various gastrointestinal disorders such as gastritis and peptic ulcer. However, most of the infections are asymptomatic and recent studies even show that Hp plays an important role in the body’s resistance to other gastrointestinal pathogens Important role. This study shows that Hp has self-tolerant antibacterial activity and that this antibacterial activity is determined by the cecropin-like N-terminal peptide possessed by ribosomal protein L1 (RpL1).