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本组高血压病患者62例,同时测定血和尿β_2微球蛋白(β_2-MG)含量及常规肾功能指标尿素氮(BUN)、肌酐(Cr)、内生肌酐清除率(Ccr),旨在评价高血压患者血和尿β_2-MG浓度改变对早期肾功能损害的诊断意义。调查表明,高血压患者血清和尿液β_2-MG阳性率显著高于血清Cr和BUN(P<0.01),并且与Cr、BUN成正相关,(r=0.634、0.8),与Ccr成负相关,(r=-0.939)。随着病程长、病情重,血、尿β_2-MG明显升高,Ⅲ期患者血、尿β_2-MG显著高于Ⅰ、Ⅱ期(0.05>P>0.01)。本组病例中还发现在Cr、BUN、Ccr正常患者中血、尿β_2-MG已升高。以上提示β_2-MG不但可以反映高血压患者肾功能的变化,而且可以较早预示肾功能的损害,可能是测定高血压患者肾功能减退的一个较敏感的指标。
In this study, 62 patients with essential hypertension were enrolled in this study. The levels of blood and urine β_2-microglobulin (β_2-MG) and routine renal function indexes (BUN, Cr, Ccr, In the evaluation of blood and urine of patients with β 2-MG concentration changes in the early diagnosis of renal damage. The results showed that the positive rate of β_2-MG in serum and urine of patients with hypertension was significantly higher than that of serum Cr and BUN (P <0.01), and positively correlated with Cr and BUN (r = 0.634,0.8), negatively correlated with Ccr (r = -0.939). Serum and urinary β_2-MG levels were significantly higher in patients with stage Ⅲ disease than those in stage Ⅰ and Ⅱ (P> 0.05). In this group of patients also found in the normal Cr, BUN, Ccr blood, urine β 2-MG has increased. The above suggests that β_2-MG can not only reflect the changes of renal function in patients with hypertension, but also can predict the damage of renal function earlier, which may be a sensitive index to determine the renal dysfunction in hypertensive patients.