论文部分内容阅读
本实验用外源性肺表面活性物质治疗家兔肺表面活性物质缺乏模型。治疗组除较非治疗组的动脉O_2分压上升、CO_2分压下降;肺磷脂增高;肺表面张力降低及肺顺应性增加外,根据病理检查其肺萎陷的面积和程度,肺透明膜数量和范围以及在电镜观察中Ⅱ型肺泡上皮细胞的变性坏死和呼吸膜的破坏程度亦较非治疗组为轻,但与基本正常尚有一段差距。基于治疗前后病理及病理生理的变化,本文对实验治疗的机理等问题着重进行了讨论。
In this experiment, exogenous pulmonary surfactant was used to treat the lack of pulmonary surfactant in rabbits. Compared with non-treatment group, arterial O 2 partial pressure increased, CO 2 partial pressure decreased, pulmonary phlebitis increased, lung surface tension decreased and lung compliance increased in the treatment group. The area and degree of pulmonary collapse, And the scope and electron microscopy in type Ⅱ alveolar epithelial cell degeneration and necrosis and the destruction of the respiratory membrane than the non-treatment group was lighter, but with the basic normal still a gap. Based on the pathological and pathophysiological changes before and after treatment, this article focuses on the mechanism of experimental treatment and other issues were discussed.