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目的:探讨主动免疫治疗对原因不明性反复自然流产(URSA)患者Th1/Th2模式表达的影响。方法:采用流式细胞仪对30例URSA患者进行主动免疫治疗前后外周血Th1/Th2模式测定,以30例正常已生育妇女作为对照。结果:UR-SA组Th1型细胞因子IFN-γ(18.98±5.37)%,明显高于对照组的(8.69±2.66)%(P<0.05);而Th2型细胞因子IL-4(5.52±0.18)%,明显少于对照组的(6.78±0.61)%(P<0.05),Th1/Th2为3.14,模式向Th1偏移。主动免疫治疗后Th2型细胞因子IL-4水平(10.27±2.04)%及Th1型细胞因子IFN-γ水平(11.73±2.47)%,Th1/Th2为1.41,模式向Th2偏移。结论:URSA患者Th1/Th2模式偏向Th1,主动免疫治疗可使Th1/Th2模式偏向Th2,诱导母胎免疫耐受,使妊娠成功。
Objective: To investigate the effect of active immunotherapy on Th1 / Th2 expression in patients with unexplained recurrent spontaneous abortion (URSA). Methods: Peripheral blood Th1 / Th2 patterns were measured by flow cytometry in 30 URSA patients before and after active immunotherapy. Thirty normal pregnant women were used as controls. Results: Th1 type cytokine IFN-γ in UR-SA group was significantly higher than that in control group (18.98 ± 5.37% vs 8.69 ± 2.66%, P <0.05), while Th2 cytokine IL- )%, Which was significantly lower than that of the control group (6.78 ± 0.61)% (P <0.05). The Th1 / Th2 was 3.14 and the pattern shifted to Th1. After active immunotherapy, the levels of Th2 cytokines IL-4 (10.27 ± 2.04)% and Th1 type cytokines IFN-γ (11.73 ± 2.47)%, Th1 / Th2 1.41, mode shift to Th2. Conclusion: The Th1 / Th2 pattern in URSA patients is biased toward Th1. Active immunotherapy may bias Th1 / Th2 pattern to Th2 and induce maternal immunotolerance, leading to successful pregnancy.