论文部分内容阅读
目的:研究血浆中一氧化氮(NO)在充血性心力衰竭(CHF)时的变化及临床意义。方法:检测18例CHF患者治疗前及治疗后血浆中的NO含量,以15例健康体检者作为对照组。结果:CHF患者血浆中NO含量显著高于健康对照组(P<0.05)且与心力衰竭的严重程度有关,治疗后NO水平下降。结论:心力衰竭患者血浆NO水平较正常对照组显著增高,心功能分级愈高其NO水平愈高,提示NO升高是CHF病理生理特征之一。
Objective: To study the changes of plasma nitric oxide (NO) in patients with congestive heart failure (CHF) and its clinical significance. Methods: The levels of NO in 18 CHF patients before and after treatment were measured. Fifteen healthy subjects were used as control group. Results: The plasma NO level in patients with CHF was significantly higher than that in healthy controls (P <0.05) and was related to the severity of heart failure. The level of NO was decreased after treatment. CONCLUSION: Plasma NO levels in patients with heart failure are significantly higher than those in normal controls. The higher the level of heart function, the higher the level of NO, suggesting that elevated NO is one of the pathophysiological features of CHF.