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目的:评价复方儿茶软膏的安全性;考察复方儿茶软膏对创伤愈合的作用。方法:对豚鼠进行皮肤急性毒性试验、刺激性和过敏性试验;建立大鼠背部全层皮肤切除模型及复方儿茶软膏高、中、低3个剂量组与阴性对照、阳性对照组,进行形态学和组织学观察、创面愈合率的比较,并对作用机制进行研究。结果:复方儿茶软膏对豚鼠无明显急性毒性反应、无刺激性、不产生局部及全身过敏反应;该软膏能促进创面愈合,高剂量组和中剂量组与阴性对照相比,差异有显著性(P<0.05);该软膏能显著的增加创面羟脯氨酸的含量及促进胶原的合成。结论:复方儿茶软膏有望成为安全有效的促进创面愈合的药物,值得进一步研究。
Objective: To evaluate the safety of compound catechu ointment and investigate the effect of compound catechu ointment on wound healing. Methods: Acute toxicity test, irritation and allergy test were performed on guinea pigs. The model of full-thickness skin excision on the back of rats and the high, middle and low dosage groups of compound catechu ointment were established. The negative control group and positive control group Learning and histological observation, the wound healing rate comparison, and the mechanism of action. Results: Compound catechu ointment had no obvious acute toxicity reaction to guinea pig, no irritation and no local or systemic allergic reaction. The ointment can promote the healing of wounds. There was significant difference between high dose group and middle dose group and negative control group (P <0.05). The ointment can significantly increase the content of hydroxyproline and promote collagen synthesis. Conclusion: Compound catechu ointment is expected to become a safe and effective drug to promote wound healing, which deserves further study.