对市售苦瓜进行了毒性及抗肿瘤活性研究，结果表明苦瓜汁经口给药ＬＤ５０ ＞ ２０ ｍｌ／ｋｇ ； 腹腔注射给药ＬＤ５０ ＝２９６－３ ｍ ｇ／ｋｇ 。苦瓜汁经口给药对Ｓ１８０ 无抑制作用，但腹腔注射则有抑制作用，抑制率达３９－３ ％ ；相反，苦瓜渣醇提物经口给药有抑制作用，抑制率达３７－１ ％ ，而腹腔注射给药则无效 The toxicity and antitumor activity of commercial bitter gourd were studied. The results showed that bitter gourd juice was administered orally with LD50 > 20 ml/kg; and LD50 =296-3 m g/kg was administered by intraperitoneal injection. There was no inhibitory effect of oral administration of bitter gourd juice on S-180, but it was inhibited by intraperitoneal injection. The inhibition rate was 39-3%. On the contrary, bitter melon residue alcohol extract was inhibited by oral administration and the inhibition rate reached 37- 1% is not effective with intraperitoneal injections