Brenner肿瘤是发生于卵巢的罕见肿瘤,约占卵巢上皮肿瘤的10%,多数肿瘤可表现为良性,偶见发生恶性病变。Brenner肿瘤被认为起源于卵巢和(或)输卵管的移行细胞化生组织,在形态学及免疫表型特征方面类似于移行上皮(尿路上皮)肿瘤,但该肿瘤的真正起源及其发病机制仍存在争议。研究证实涉及TERT启动子区的基因突变是泌尿上皮肿瘤常发生的分子遗传学异常(高达70%),主要类型包括 Brenner tumor is a rare tumor in the ovary, accounting for about 10% of ovarian epithelial tumors, most tumors can be benign, occasionally malignant lesions. Brenner tumors are thought to originate from metaplastic metaplasia of the ovary and / or oviduct and resemble migrating epithelial (urothelial) tumors in morphological and immunophenotypic characteristics but the true origin and pathogenesis of this tumor remains there is controversy. Studies confirm that gene mutations involving the TERT promoter region are molecular genetic abnormalities (up to 70%) often found in urothelial tumors, and the major types include