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目的将橡胶职业暴露人群肺癌死亡率与普通人群比较,估计其肺癌危险度及肺癌在工种间的聚集性。方法对某橡胶厂工人进行23年(1973—1995年)随访,应用标化死亡率比(SMR)分析。结果男女性工人肺癌死亡率轻度增高,SMR分别为1.22(95%CI:0.58~2.24)和1.26(95%CI:0.90~1.71)。肺癌死亡率在不同工种间差别有显著意义(一致性检验P=0.002),表现为硫化、胶鞋、内胎、炼胶等工种组的肺癌死亡超额在47%~124%之间。结论本文数据提示肺癌在硫化及相关工种有明显的聚集,这为进一步研究提供了病因线索
Objective To compare the risk of lung cancer death among occupational population exposed by rubber to the general population, and to estimate the risk of lung cancer and the clustering of lung cancer among the types of work. Methods The workers of a rubber factory were followed for 23 years (1973-1995), and the standardized mortality ratio (SMR) analysis was used. Results The mortality rate of lung cancer in male and female workers increased slightly, with SMR of 1.22 (95% CI: 0.58 to 2.24) and 1.26 (95% CI: 0.90 to 1.71), respectively. There was a significant difference in lung cancer mortality among different types of work (P<0.00 for consistency check), and the excess mortality for lung cancer in work groups such as vulcanization, rubber shoes, inner tubes, and rubber refining ranged from 47% to 124%. Conclusions This data suggests that there is a clear accumulation of lung cancer in the vulcanization and related work types, which provides etiologic clues for further studies.