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研究目的:研究停经70天以内的高危人流对象早孕药流的安全性、有效性及可接受性.对象和方法:疤痕子宫、生殖道畸形、子宫肌瘤、近期人流、多次人流、哺乳期妊娠等高危人流对象388例,停经34～69天,口服米非司酮25mgq12h×5次,首次剂量50mg(总量150mg),第3天上午口服米索前列醇600μg.结果:完全流产率92.3%,不全流产率 6.2%,失败率1.5%.结论:口服米非司酮合并米索前列醇能有效地终止高危人流对象早孕,其效果与一般人群药流效果相似,其安全性、有效性和可接受性令人满意.此外,由于用药后宫颈软化、宫口扩张,即使药流失败也易于吸宫术的施行,减轻受术者的痛苦.
Objectives: To study the safety, efficacy and acceptability of early pregnancy abortion in high-risk abortion subjects within 70 days after menopause.Methods: The uterus, reproductive tract deformity, uterine fibroids, recent abortion, multiple abortion, lactating pregnancy 388 cases of high-risk human flow, menopause 34 to 69 days, oral mifepristone 25mgq12h × 5 times the first dose of 50mg (total 150mg), the morning of the 3rd day oral misoprostol 600μg.Results: The complete abortion rate of 92.3% , The rate of incomplete abortion was 6.2% and the failure rate was 1.5% .Conclusion: Oral mifepristone combined with misoprostol can effectively terminate early pregnancy of high-risk abortion subjects with similar efficacy to that of the general population, and its safety, efficacy and feasibility Acceptability is satisfactory.In addition, due to cervical softening after treatment, cervix expansion, even if the failure of medical abortion is also easy to use the implementation of ejaculation, reduce the suffering of the surgeon.