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目的：探讨异丙酚对单肺通气（ＯＬＶ）时缺氧性肺血管收缩（ＨＰＶ）、肺内分流（Ｑｓ／Ｑｔ）的影响。方法：观察组用异丙酚６～１２ｍｇ·ｋｇ－１·ｈ－１静注，对照组用不抑制ＨＰＶ、对Ｑｓ／Ｑｔ无影响的普鲁卡因４０～６０ｍｇ·ｋｇ－１·ｈ－１静滴。观察两组ＯＬＶ不同时期Ｑｓ／Ｑｔ、ＰａＯ２、ＰｖＯ２、ＰａＣＯ２和ｐＨ值变化。结果：ＯＬＶ时两组病人Ｑｓ／Ｑｔ明显升高，ＰａＯ２明显下降（Ｐ＜０．０１），ＰｖＯ２、ｐＨ、ＰａＣＯ２无明显变化。ＯＬＶ时，两组病人的Ｑｓ／Ｑｔ和ＰａＯ２组内不同时值或组间同时值比较均无显著差异（Ｐ＞０．０５）。结论：异丙酚不抑制ＯＬＶ时ＨＰＶ，对Ｑｓ／Ｑｔ无明显影响，ＯＬＶ时无低氧、高碳酸血症和酸碱失衡。
Objective: To investigate the effect of propofol on hypoxic pulmonary vasoconstriction (HPV) and pulmonary shunt (Qs / Qt) during one lung ventilation (OLV). Methods: The observation group was treated with propofol 6 ~ 12mg · kg-1 · h-1. The control group was treated with procaine 40 ~ 60mg · kg-1 · h-1 without any effect on the Qs / 1 intravenous infusion. The changes of Qs / Qt, PaO2, PvO2, PaCO2 and pH value of OLV in different periods were observed. Results: The Qs / Qt of both groups were significantly increased, PaO2 was significantly decreased (P <0.01), and there was no significant change of PvO2, pH and PaCO2 in OLV patients. OLV, there was no significant difference (P> 0.05) between the two groups of Qs / Qt and PaO2 group at different time or between groups. CONCLUSION: Propofol does not inhibit HPV in OLV and has no obvious effect on Qs / Qt. There is no hypoxemia, hypercapnia and acid-base imbalance in OLV.