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真核细胞内大多数蛋白质降解过程的调控是通过泛素-蛋白酶体通路(UPP)进行的。该过程分为两个步骤:①蛋白质的泛素化:一个或多个泛素分子通过共价键连接在目标蛋白质上;②多泛素化的蛋白质被26S蛋白酶体降解成寡肽。26S蛋白酶体是一个多亚单位的蛋白酶复合体,它可分为一个19S具
The regulation of most protein degradation processes in eukaryotes is through the ubiquitin-proteasome pathway (UPP). The process is divided into two steps: ① protein ubiquitination: one or more ubiquitin molecules covalently linked to the target protein; ② polyubiquitinated protein 26S proteasome degradation into oligopeptides. The 26S proteasome is a multi-subunit protease complex that can be divided into a 19S