目的　观察解酒护肝饮对大鼠酒精性肝损伤病理组织学的影响 ,为临床治疗酒精性肝损伤提供实验依据。方法　以益肝灵、葛花解酲汤为对照 ,采用白酒灌胃造模 ,治疗给药后 ,于各组大鼠肝脏取材 ,常规HE染色 ,光镜观察。结果　模型组肝正常组织结构消失 ,小叶界限不清 ,细胞索紊乱 ,大部分肝窦消失 ,肝细胞呈中到重度水肿 ,以至灶状坏死。多数细胞核体积缩小、深染 ,核膜轻度皱缩 ;解酒护肝饮治疗组小叶结构清晰 ,细胞索排列整齐 ,但肝窦轻度狭窄。肝细胞损伤较轻 ,或仅有轻度浊肿及胞浆疏松。结论　解酒护肝饮能有效治疗酒精性肝损伤。 Objective To observe the effect of Jiejiu Gangan Decoction on the histopathology of alcoholic liver injury in rats, and provide experimental evidence for clinical treatment of alcoholic liver injury. Methods Yiganling and Gehua Jieyu Decoction were used as the control. The model was made by intragastric gavage. After treatment, the liver of each group was obtained and routinely stained with HE and observed by light microscope. Results The normal liver tissue structure disappeared in the model group. The boundary of the lobule was unclear, the cell cable was disordered, most of the sinusoids disappeared, the liver cells showed moderate to severe edema, and even focal necrosis. Most of the nuclei were reduced in size, deep-stained, and the nuclear membrane shrank slightly; the lobule structure of the treatment group was clear and the cell lines were arranged neatly, but the liver sinus was slightly stenosis. Hepatocyte damage is mild, or only mild edema and cytoplasm are loose. Conclusion Jiejiu Hugan Decoction can effectively treat alcoholic liver injury.