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【目的】探讨痰液降钙素原(procalcitonin,PCT)测定在婴幼儿喘息中指导抗生素使用的价值。【方法】用一次性吸痰管吸取深部痰液,采用免疫色谱法测定PCT。【结果】痰细菌培养阳性者痰PCT阳性率88.4%,痰培养阴性者痰液PCT阳性率仅14.0%,差异有统计学意义(P=0.000);痰细菌培养阳性者于抗生素治疗3~5 d复查痰液PCT仍有53.5%阳性,明显高于血清PCT和痰培养(P<0.05),临床症状、体征消除后复查各指标均恢复正常。【结论】痰液PCT检测值高于血清PCT检测和细菌培养,可以作为协助判断喘息患儿细菌感染的指标,减少抗生素的不合理使用。
【Objective】 To investigate the value of sputum procalcitonin (PCT) in guiding the use of antibiotics in infantile asthma. 【Method】 Deep sputum was aspirated with a disposable suction tube and PCT was determined by immunochromatography. 【Results】 The sputum PCT positive rate was 88.4% in sputum culture positive and sputum PCT positive rate was only 14.0% in sputum culture negative, the difference was statistically significant (P = 0.000); sputum bacterial culture positive in antibiotic treatment 3 ~ 5 PCT still sputum PCT 53.5% positive, significantly higher than the serum PCT and sputum culture (P <0.05), clinical symptoms, signs disappeared after the review of the indicators returned to normal. 【Conclusion】 The sputum PCT detection value is higher than serum PCT detection and bacterial culture, which can be used as an index to help determine the bacterial infection in children with wheezing and reduce the irrational use of antibiotics.