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为探讨清热解毒制剂热毒清注射液对人类免疫缺陷病毒（ＨＩＶ）在细胞内复制的影响，以ＭＴ－４细胞为靶细胞，并转染ＨＩＶ－１，从热毒清对靶细胞的亚毒性浓度始作对倍稀释，观察不同浓度热毒清对ＨＩＶ诱导细胞病变程度的影响。结果表明，热毒清亚毒性浓度（ＳＣ）为 ６．２５ｍｇ／ｍｌ，５０％有效浓度（ＥＣ５０）为０．４７３ｍｇ／ｍｌ，在 ０．７８１～６．２５ｍｇ／ｍｌ剂量范围内，能明显抑制ＨＩＶ－１在ＭＴ－４细胞内的复制。结果提示：热毒清注射液具有较强的抗ＨＩＶ－１的作用。
To investigate the effect of Qingrejiedu formulation geduqing injection on intracellular replication of human immunodeficiency virus (HIV), MT-4 cells were used as target cells and transfected with HIV-1. Toxicity concentration was used for double dilution, and the effect of different concentrations of hot toxic solution on HIV-induced cytopathic effect was observed. The results showed that the toxicant concentration (SC) was 6.25 mg/ml, the 50% effective concentration (EC50) was 0.473 mg/ml, and it was significantly inhibited in the dose range of 0.781 to 6.25 mg/ml. HIV-1 replication in MT-4 cells. The results suggest that Reduqing Injection has a strong anti-HIV-1 effect.