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目的探讨纳洛酮药物治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的临床效果。方法选取本院2012年4月~2013年3月收治的慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者130例,随机分为对照组与观察组各65例,对照组患者给予常规治疗,观察组患者在常规治疗的基础上增加纳洛酮的使用,观察两组患者的临床效果并开展比较分析。结果治疗后,两组患者的PaO2、PaCO2及SaO2均有所改善,观察组的改善效果更显著,差异具有统计学意义(P<0.05);对照组治疗有效51例,总有效率为78.46%,观察组治疗有效59例,总有效率为90.77%,观察组疗效显著好于对照组,差异具有统计学意义(P<0.05)。结论应用纳洛酮药物治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者,能够有效改善患者的症状,缓解呼吸功能紊乱,具有良好的临床疗效。
Objective To investigate the clinical effect of naloxone on chronic obstructive pulmonary disease (COPD) with type Ⅱ respiratory failure. Methods A total of 130 patients with chronic obstructive pulmonary disease and type Ⅱ respiratory failure admitted to our hospital from April 2012 to March 2013 were randomly divided into control group and observation group with 65 cases each. Patients in control group were given routine treatment and observation group Patients on the basis of conventional therapy to increase the use of naloxone to observe the clinical effect of two groups of patients and carry out comparative analysis. Results After treatment, the PaO2, PaCO2 and SaO2 in both groups were improved, the improvement effect in the observation group was more significant, the difference was statistically significant (P <0.05); 51 cases were effective in the control group, the total effective rate was 78.46% . The effective rate of the observation group was 59.77%, the effect of the observation group was significantly better than that of the control group, the difference was statistically significant (P <0.05). Conclusion The application of naloxone in patients with chronic obstructive pulmonary disease and type Ⅱ respiratory failure can effectively improve the symptoms of patients and relieve respiratory dysfunction, and has good clinical efficacy.