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据《美国医学论坛报》(1993,8,5)报道 经过改良的血管镜可使医生看到在超声图像仪上只有一个污斑大小的人胚胎。 这种直径0.7mm的胚胎胎儿镜(embryofeto-scope,E)现已可经腹腔对早至妊娠10周的胚胎进行先天性畸形的诊断,并可获得胚胎解剖与生理学特征的精确图像。该镜的研制者,美国底特律市韦恩州大学Hutzel医院的产科医师R Quintero迄今已用此技术于60名孕妇,成功率达85％而无不良作用。只在选用局麻的妇女发生过痛性痉挛。15％的失败率是因孕妇肥胖、子宫极度后倾、胚胎或胎儿过小所致。 目前这一技术最多用于检测像Meckel—Gruber综合征那样有明显畸形的遗传性疾病。但Quintero认为,经腹腔E不久即可用于妊娠头1/3期内的脐带穿刺术和一些创新住疗法如细胞移植、基因治疗以及胎儿外科。即便这一技术能用于观察早于妊娠10周的胚胎,但他建议不要这样做,因“胚胎发生尚不完全,胎儿仍在发育之中。”
According to the American Medical Tribune (August 5, 1993), reported improvements to the scope of the vascular scope allow the physician to see only one spot-sized human embryo on the ultrasound imager. The 0.7-mm diameter embryofeto-scope (E) now allows the diagnosis of congenital malformations of embryos as early as 10 weeks of gestation via the abdominal cavity and provides an accurate picture of embryonic anatomy and physiology. The researcher R Quintero, an obstetrician at Hutzel Hospital at Wayne State University in Detroit, USA, has so far applied this technique to 60 pregnant women with a success rate of 85% without adverse effects. Only in the use of local anesthesia women had cramps. The failure rate of 15% is due to obesity in pregnant women, extreme lean uterus, embryos or fetuses too small. At present, this technique is used at the most to detect genetic diseases that have obvious deformities like Meckel-Gruber syndrome. However, Quintero argues that transabdominal E can soon be used for umbilical cord aspiration during the first trimester of pregnancy and a number of innovative inpatient treatments such as cell transplantation, gene therapy and fetal surgery. Even though this technique can be used to visualize embryos 10 weeks earlier than pregnancy, he recommends not doing so because “the embryo is not yet complete and the fetus is still developing.”