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目的比较足月儿与早产儿血酪酪肽(PYY)和葛瑞林水平变化及其与体质量的相关性,探讨2种激素与早产儿、足月儿营养状况及生长发育的关系。方法利用放射免疫技术,分别于出生当日、出生第3天及第7天测定20例早产儿(早产儿组)血清PYY、葛瑞林水平,同时测定20例足月儿(足月儿组)出生第7天PYY、葛瑞林水平。同时详细记录2组体质量等生长发育指标,比较2组血清中2种激素水平,并分析其与体质量的关系。结果出生第7天,与足月儿组相比,早产儿组血PYY、葛瑞林水平显著升高[足月儿PYY:(601.9±206.2)ng.L-1,葛瑞林:(1 064.5±208.6)ng.L-1;早产儿PYY:(812.4±153.8)ng.L-1,葛瑞林:(1 485.4±409.2)ng.L-1,Pa<0.01]。早产儿出生时、出生第3天时PYY、葛瑞林水平与出生第7天时比较差异均有统计学差异(Pa<0.01),而出生时与出生第3天比较无统计学差异。早产儿PYY与葛瑞林呈正相关,且均与体质量呈负相关。结论早产儿血清葛瑞林及PYY水平较足月儿高,PYY和葛瑞林均可反映新生儿的营养状况,并且作为能量代谢负平衡的一种代偿,2种激素间可能存在相互作用。
Objective To compare the changes of serum progesterone (PYY) and glibenclamide (PGE) levels and their correlation with body weight in full-term infants and premature infants, and to explore the relationship between the two hormones and the nutritional status and growth of premature infants and full-term infants. Methods The levels of serum PYY and glibenclamide in 20 preterm infants (premature infants) were measured by radioimmunoassay on the day of birth, 3 days and 7 days after birth, and 20 infants (full-term infants) 7 days PYY, Gerui Lin level. At the same time, two groups of body weight and other growth indicators were recorded in detail. The levels of two hormones in the two groups were compared and their relationship with body weight was analyzed. Results Compared with full-term infants, the levels of PYY and glibenclamide were significantly increased in preterm infants on day 7 [PYY of full-term infants: (601.9 ± 206.2) ng.L-1 and (0 064.5 ± 208.6) (812.4 ± 153.8) ng.L-1, and berrylin: (1 485.4 ± 409.2) ng.L-1, Pa <0.01]. At birth, the levels of PYY and glibenclamide on day 3 of birth were significantly different from those on day 7 of birth (Pa <0.01), but no significant difference was found between birth and day 3 of birth. PYY in preterm infants was positively correlated with Gerui Lin, and both were negatively correlated with body mass. Conclusions Serum glibenclamide and PYY levels in preterm infants are higher than those in full-term infants. PYY and glibenclamide reflect the nutritional status of newborn infants. As a compensatory negative balance of energy metabolism, there may be interactions between the two hormones.