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目的探讨急性脑梗死(ACI)患者细胞因子信号转导抑制因子3(SOCS-3)及TNF-α和白细胞介素6(IL-6)水平变化的临床意义。方法选择发病<72 h的ACI患者65例作为脑梗死组,同期选择年龄匹配的健康体检者20例作为对照组。脑梗死组按不同梗死体积、不同神经功能缺损进行分析,对照组体检时,脑梗死组入院第1、3、7天用ELISA检测血清SOCS-3水平,用化学发光法检测入院第1、7天血清IL-6与TNF-α水平,并进行相关分析。结果与对照组比较,脑梗死组第1、3、7天SOCS-3、IL-6和TNF-α明显上升(P<0.01),大梗死体积患者IL-6和TNF-α表达较中、小梗死体积患者明显上升(P<0.05)。入院第21天Barthel指数与SOCS-3水平呈正相关(r=0.810,P<0.05),与IL-6、TNF-α水平呈负相关(r=-0.672,-0.822,P<0.05)。结论 SOCS-3可能参与ACI炎性反应发生、发展的病理过程,观察SOCS-3的变化,对ACI病情评价及预后分析有益。
Objective To investigate the clinical significance of the changes of cytokine signaling inhibitor 3 (SOCS-3), TNF-α and interleukin 6 (IL-6) in patients with acute cerebral infarction (ACI) Methods Sixty-five ACI patients with onset of <72 h were selected as cerebral infarction group and 20 age-matched healthy subjects were selected as control group. The cerebral infarction group was analyzed by different infarct volume and different neurological deficits. In the control group, SOCS-3 levels were detected by ELISA on the 1st, 3rd, 7th day after admission on the 1st, Day serum IL-6 and TNF-α levels, and correlation analysis. Results Compared with the control group, the levels of SOCS-3, IL-6 and TNF-α in the cerebral infarction group were significantly increased on the 1st, 3rd, 7th day (P <0.01) Patients with small infarct volume increased significantly (P <0.05). Barthel index was positively correlated with SOCS-3 on day 21 (r = 0.810, P <0.05), and negatively correlated with IL-6 and TNF-α (r = -0.672, -0.822, P <0.05). Conclusion SOCS-3 may be involved in the pathogenesis of ACI inflammatory reaction and the development of SOCS-3. It may be helpful to evaluate the prognosis and prognosis of ACI.