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癌变的早期诊断对提高疗效具有特殊意义。为寻求简捷、高效、超前、可靠的诊断口腔粘膜癌前病变的方法，实验以DMBA（二甲基苯并蒽）诱导的金地鼠颊囊致癌模型为对象，采用PCNA（增殖细胞核抗原）、BrdU（溴脱氧尿嘧啶）核标记技术手段检测颊囊粘膜组织，并与经典的光镜观察诊断作对照。对三种观察结果行相关分析，发现三者间有高度显著的相关性，证实免疫组化方法在癌变诊断中的实用价值。实验还发现PCNA和BraU检测结果比较敏感、简捷，可靠性较好，因而是有希望的早期诊断癌变的手段之一。
Early diagnosis of cancer has the special meaning of improving the curative effect. In order to find a simple, efficient, advanced and reliable method for the diagnosis of oral mucosal precancerous lesions, the experimental model of the hamster cheek pouch carcinogenicity induced by DMBA (dimethylbenzanthracene) was used in this study. PCNA (proliferating cell nuclear antigen), BrdU (Bromodeoxyuridine) nuclear marker technology to detect cheek pouch mucosa, and with the classic diagnosis of light microscopy as a control. Correlation analysis of the three observation results found that there was a highly significant correlation between the three, confirming the practical value of immunohistochemistry in the diagnosis of cancer. The experiment also found that PCNA and BraU test results are more sensitive, simple and reliable, so it is promising one of the means of early diagnosis of cancer.